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Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations

Ebtehal M. Husseiny, Hamada S. Abulkhair, Asmaa Saleh, Najla Altwaijry, Riham A. Zidan, Fatma G. Abdulrahman

2023Bioorganic Chemistry20 citationsDOI

Topics & Concepts

ChemistryCyclin-dependent kinase 2Combinatorial chemistryComputational biologyNanotechnologyBiochemistryPhosphorylationProtein kinase AMaterials scienceBiologySynthesis and Reactivity of HeterocyclesClick Chemistry and Applications
Molecular overlay-guided design of new CDK2 inhibitor thiazepinopurines: Synthesis, anticancer, and mechanistic investigations | Litcius