Hematopoietic stem cell mobilization for allogeneic stem cell transplantation by motixafortide, a novel CXCR4 inhibitor
Zachary Crees, Michael P. Rettig, Asad Bashey, Steven M. Devine, Samantha Jaglowski, Fei Wan, Amy Zhou, Melinda Harding, Abi Vainstein‐Haras, Ella Sorani, Irit Gliko-Kabir, Brenda J. Grossman, Peter Westervelt, John F. DiPersio, Geoffrey L. Uy
Abstract
Motixafortide injection enabled 92% of allogeneic stem cell donors to collect 2.0×10^6 CD34+ cells/kg or more within 2 apheresis procedures.
Topics & Concepts
CXCR4MobilizationStem cellTransplantationHematopoietic stem cell transplantationPlerixaforHaematopoiesisHematopoietic cellImmunologyCell biologyCancer researchBiologyMedicineInternal medicinePolitical scienceImmune systemChemokineLawHematopoietic Stem Cell TransplantationImmunotherapy and Immune ResponsesChemokine receptors and signaling