The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-related miRNAs
Xiaoyi Zhao, Fangang Meng, Shu Hu, Zibo Yang, Hao Huang, Rui Pang, Xingzhao Wen, Yan Kang, Zhiqi Zhang
Abstract
experiments, we found that Runx1 can bind to the promoter regions of miR-455 and miR-210 and enhance their transcription in TGF-β1-treated synoviocytes. Collectively, our findings demonstrate a protective effect of the synovium against cartilage degeneration mediated by chondrogenesis-related miRNAs, which suggests that Runx1 is a potential target for KOA therapy.
Topics & Concepts
ChondrogenesismicroRNACartilageDegeneration (medical)RUNX1CascadeCell biologyCancer researchMedicineBiologyChemistryAnatomyPathologyStem cellGeneGeneticsHaematopoiesisChromatographyOsteoarthritis Treatment and MechanismsCancer-related molecular mechanisms researchMicroRNA in disease regulation