Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives
Zofia Bernat, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych
Abstract
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.
Topics & Concepts
TriazineCytotoxic T cellChemistryCombinatorial chemistryStereochemistryCytotoxicityCancer cell linesCancerIn vitroCancer cellBiologyBiochemistryOrganic chemistryGeneticsSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityEnzyme function and inhibition