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Aloe-emodin mitigates cisplatin-induced acute kidney injury by Nrf2-mediated ferroptosis regulation

Qiangfang Dai, Yang Xiang, Rongrong Qiang, Gen Li, Yuxuan Song, Yanxin Yu, Jing Liu, Mengdi Lv, Wenqi Liu, Jumei Zhao, Xiaoli Wei, Xiaolong Liu

2025Free Radical Biology and Medicine10 citationsDOI

Topics & Concepts

Acute kidney injuryMedicineOxidative stressKidneyCisplatinPharmacologyRenal functionKidney diseasePathologicalCancer researchNephrotoxicityReactive oxygen speciesIn vivoKEAP1AntioxidantDrugCancerIn vitroBioinformaticsMechanism (biology)GlutathioneInternal medicineSignal transductionAnimal studiesClinical trialOxidative phosphorylationChemotherapy-induced organ toxicity mitigationFerroptosis and cancer prognosisRenal and related cancers
Aloe-emodin mitigates cisplatin-induced acute kidney injury by Nrf2-mediated ferroptosis regulation | Litcius