Integrated network pharmacology and metabolomics reveal the action mechanisms of vincristine combined with celastrol against colon cancer
Jinyu Ning, Bo Ma, Jing-yi Huang, Liang Han, Yan-hua Shao, Fengyun Wang
Topics & Concepts
PI3K/AKT/mTOR pathwayColorectal cancerPharmacologyApoptosisCancer researchProtein kinase BCancerCancer cellSignal transductionVincristineMetabolomicsAKT1ChemistryMedicineBiologyBioinformaticsBiochemistryChemotherapyInternal medicineCyclophosphamideNatural Compounds in Disease TreatmentNatural product bioactivities and synthesisBioactive Compounds and Antitumor Agents