Anti-HIV and anti-HCV small molecule protease inhibitors in-silico repurposing against SARS-CoV-2 M <sup>pro</sup> for the treatment of COVID-19
Armiya Sultan, Rafat Ali, Romana Ishrat, Sher Ali
Abstract
, here we report the small drug molecule namely saquinavir as its potent inhibitor. Findings support the premise that this promising antiviral protease inhibiting small drug molecule can be validated and implemented for the treatment and clinical management of COVID-19 pandemic disease.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
ProteaseDrug repositioningVirologyRepurposingSaquinavirIndinavirCoronavirusViral replicationDrug discoveryProtease inhibitor (pharmacology)In silicoSmall moleculeAntiviral drugDrugCoronavirus disease 2019 (COVID-19)PharmacologyBiologyMedicineViral loadVirusEnzymeInfectious disease (medical specialty)BioinformaticsDiseaseBiochemistryGeneAntiretroviral therapyPathologyEcologySARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsHepatitis C virus research