Genomic Analysis of Mycobacterium abscessus Complex Isolates Collected in Ireland between 2006 and 2017
Natalia Redondo, Simone Mok, Lorraine Montgomery, Peter R. Flanagan, Eleanor McNamara, E.G. Smyth, Niamh O’Sullivan, Kirsten Schaffer, Thomas R. Rogers, Margaret Fitzgibbon
Abstract
Members of the Mycobacterium abscessus complex (MABC) are multidrug-resistant nontuberculous mycobacteria and cause opportunistic pulmonary infections in individuals with cystic fibrosis (CF). In this study, genomic analysis of MABC isolates was performed to gain greater insights into the epidemiology of circulating strains in Ireland. Whole-genome sequencing (WGS) was performed on 70 MABC isolates that had been referred to the Irish Mycobacteria Reference Laboratory between 2006 and 2017 across nine Irish health care centers.
Topics & Concepts
Nontuberculous mycobacteriaBiologyMycobacterium abscessusMycobacterium avium complexIrishMicrobiologyMycobacteriumGenomeCystic fibrosisGeneticsGeneBacteriaLinguisticsPhilosophyMycobacterium research and diagnosisInfectious Diseases and MycologyActinomycetales infections and treatment