A fluorescent molecular rotor probe for tracking plasma membranes and exosomes in living cells
Ling Feng, Yusheng Xie, Sung-king Au Yeung, Hagos Birhanu Hailu, Zhiyang Liu, Qingxin Chen, Jie Zhang, Qiuxiang Pang, Xi Yao, Mengsu Yang, Liang Zhang, Hongyan Sun
Abstract
A rotor-based probe MRMP-1 was designed and synthesized. MRMP-1 can bind to plasma membranes very quickly and stably with remarkable fluorescence enhancement. It can be used to monitor the dynamic changes in cell membranes in real-time under stimuli conditions. Importantly, MRMP-1 is the first rotor-based fluorescent sensor to label exosomes in living cells.
Topics & Concepts
MicrovesiclesFluorescenceMembraneRotor (electric)PlasmaTracking (education)BiophysicsChemistryBiologyBiochemistryPhysicsmicroRNAGeneOpticsPedagogyPsychologyQuantum mechanicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques