Miniproteins in medicinal chemistry
Agnieszka Ciesiołkiewicz, Juan Lizandra Pérez, Łukasz Berlicki
Abstract
Miniproteins exhibit great potential as scaffolds for drug candidates because of their well-defined structure and good synthetic availability. Because of recently described methodologies for their de novo design, the field of miniproteins is emerging and can provide molecules that effectively bind to problematic targets, i.e., those that have been previously considered to be undruggable. This review describes methodologies for the development of miniprotein scaffolds and for the construction of biologically active miniproteins.
Topics & Concepts
ChemistryDrug discoveryCombinatorial chemistryDrug developmentComputational biologyDrugBiochemistryPharmacologyBiologyBiochemical and Structural CharacterizationGlycosylation and Glycoproteins ResearchMonoclonal and Polyclonal Antibodies Research