Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Sherif S. Ebada, Nariman A. Al-Jawabri, Fadia S. Youssef, Dina H. El‐Kashef, Tim‐Oliver Knedel, Amgad Albohy, Michal Kořínek, Tsong‐Long Hwang, Bing‐Hung Chen, Guan-Hua Lin, Chia-Yi Lin, Sa’ed M. Aldalaien, Ahmad M. Disi, Christoph Janiak, Peter Proksch
Abstract
, supported by docking and molecular dynamic studies, strengthens its potential as a lead structure paving the way toward finding out a natural remedy to treat and/or to control the current COVID-19 pandemic.
Topics & Concepts
PhytochemicalProteaseIn silicoChemistryCoronavirus disease 2019 (COVID-19)Traditional medicineFlavonolsPolyphenolDocking (animal)Inhibitory postsynaptic potentialBiologyBiochemistryMedicineEnzymeAntioxidantInfectious disease (medical specialty)NursingPathologyNeuroscienceGeneDiseaseEssential Oils and Antimicrobial ActivityDrug-Induced Hepatotoxicity and ProtectionPharmacological Effects of Natural Compounds