A Dual-Specificity Inhibitor Targets Polyphosphate Kinase 1 and 2 Enzymes To Attenuate Virulence of Pseudomonas aeruginosa
Nolan Neville, Nathan Roberge, Xiang Ji, Preyesh Stephen, Jiasheng Lu, Zongchao Jia
Abstract
knockout control. Treatment also attenuated biofilm formation, motility, toxin production, and virulence to a similar extent, thereby elucidating a hitherto-undocumented role of PPK2 enzymes in P. aeruginosa virulence phenotypes. This work therefore establishes PPK2s, in addition to PPK1, as valuable drug targets in P. aeruginosa and provides a favorable starting molecule for future inhibitor design efforts.
Topics & Concepts
Pseudomonas aeruginosaBiofilmVirulencePolyphosphateMicrobiologyBiologyPyocyaninEnzymeBacteriaCell biologyBiochemistryQuorum sensingGeneGeneticsPhosphateCoagulation, Bradykinin, Polyphosphates, and AngioedemaEnzyme function and inhibitionOral and gingival health research