Aporphinoid alkaloids inhibit biofilm formation of <i>Yersinia enterocolitica</i> isolated from sausages
Natalia Indira Di Marco, Carlos R. Pungitore, Cecilia S.M. Lucero Estrada
Abstract
AIMS OF THE STUDY: The ability of Yersinia enterocolitica strains to form biofilms and the capacity of different alkaloids to inhibit biofilm formation were investigated. METHODS AND RESULTS: at subinhibitory concentration and also was able to inhibit QS system and reduce yenR expression at this concentration. CONCLUSION: This is the first study to demonstrate that oliverine, liriodenine, and pachypodanthine are able to inhibit biofilm formation of Y. enterocolitica without critically disturbing its growing capacity. At MBIC, pachypodanthine inhibited biofilm formation and QS. SIGNIFICANCE AND IMPACT OF THE STUDY: The use of aporphinoid alkaloids as biofilms inhibitory agents might potentially be useful to treat biofilm-associated infections in the future.