Design, synthesis and bioactivity of myricetin derivatives for control of fungal disease and tobacco mosaic virus disease
Xiao Cao, Bangcan He, Fang Liu, Yuanquan Zhang, Xing Li, Nian Zhang, Yuanxiang Zhou, Chenyu Gong, Wei Xue
Abstract
) value of 0.855 μM, which was better than ningnanmycin (2.244 μM). Further molecular docking revealed that Y18 interacts with multiple key amino acid residues of TMV-CP, which may hinder the self-assembly of TMV particles. Overall, after the introduction of isoxazole on the structure of myricetin, its anti-Ss and anti-TMV activities have been significantly improved, which can be further studied.
Topics & Concepts
Tobacco mosaic virusDiseaseMyricetinVirologyDisease controlBiologyChemistryMedicineVirusOrganic chemistryInternal medicineKaempferolAntioxidantQuercetinFungal Plant Pathogen ControlPlant Disease Resistance and GeneticsPlant-Microbe Interactions and Immunity