DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway
Qingqing Wang, Fengxia Chen, Ningning Yang, Lu Xu, Xiaoyan Yu, Meng Wu, Yunfeng Zhou
Abstract
By using bioinformatics analysis and the experimental techniques of cell biology and molecular biology, we found that DEP domain-containing protein 1B (DEPDC1B) can promote the invasion and migration of breast cancer cells and that DEPDC1B mediates the deubiquitination of β-catenin by ubiquitin-specific protease 5 (USP5), thus activating the wnt/β-catenin pathway. Our findings provide new insights into the carcinogenic mechanism of DEPDC1B, suggesting that DEPDC1B can be used as a potential therapeutic target for breast cancer.
Topics & Concepts
Wnt signaling pathwayCateninDeubiquitinating enzymeCancer researchMetastasisBreast cancerUbiquitinCell biologyBiologyMechanism (biology)CancerSignal transductionGeneticsGenePhysicsQuantum mechanicsUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysHistone Deacetylase Inhibitors Research