A photo-triggering double cross-linked adhesive, antibacterial, and biocompatible hydrogel for wound healing
Honghua Hu, Xinrang Zhai, Wenyue Li, Shunxian Ji, Wei Dong, Weiyu Chen, Wei Wei, Zhongfa Lu
Abstract
experiments confirmed that CM/GN could promote wound healing by generating more hair follicles and mutual blood vessels, high fibroblasts density, and thicker granulation tissue thickness. In addition, reduced secretions of tumor necrosis factor-α (TNF-α) and enhanced secretions of vascular endothelial growth factor (VEGF) could be observed in regenerated tissues after CM/GN treatment. These results suggested that CM/GN hydrogels could be promising candidates to promote wound healing.
Topics & Concepts
Self-healing hydrogelsWound healingDermisGranulation tissueGelatinBiomedical engineeringSkin repairAdhesiveChitosanAngiogenesisChemistryIn vivoMaterials scienceNanotechnologyPathologySurgeryCancer researchMedicinePolymer chemistryBiologyBiochemistryBiotechnologyLayer (electronics)Wound Healing and TreatmentsSilk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical Applications