Bone-targeted ICG/Cyt c@ZZF-8 nanoparticles based on the zeolitic imidazolate framework-8: a new synergistic photodynamic and protein therapy for bone metastasis
Zichao Jiang, Yixiao Pan, Jiahao Wang, Jingyi Li, Haoze Yang, Qi Guo, Shuailong Liang, Sijie Chen, Yihe Hu, Long Wang
Abstract
, thus enhancing the PDT efficiency. The ZOL can further inhibit bone resorption. The ICG/Cyt c@ZZF-8 NPs showed improved antitumor and bone protection efficiency in a mouse model of BM. This study demonstrated a potential mode for the synergetic therapy of orthopedic diseases.
Topics & Concepts
Photodynamic therapyChemistryImidazolateBone metastasisIn vivoCancer researchIndocyanine greenCytochrome cApoptosisBiophysicsMetastasisBiochemistryPathologyCancerMedicineInorganic chemistryBiologyBiotechnologyOrganic chemistryInternal medicineNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesBone health and treatments