Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent <i>N</i>-Sulfinyl-<i>O</i>-(<i>tert</i>-butyl)hydroxylamine, <i>t</i>-BuONSO
Thomas Q. Davies, Michael J. Tilby, David Skolc, Adrian Hall, Michael C. Willis
Abstract
-BuONSO. A variety of (hetero)aryl and alkyl Grignard and organolithium reagents perform well in the reaction, providing primary sulfonamides in good to excellent yields in a convenient one-step process.
Topics & Concepts
ReagentChemistrySulfonamideHydroxylamineArylPrimary (astronomy)Combinatorial chemistryOrganic chemistryAlkylMedicinal chemistryAstronomyPhysicsSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions