Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance
Bao Cheng, Guirong Zhu, Linghua Meng, Guolin Wu, Qin Chen, Shengming Ma
Topics & Concepts
ChemistryTubulinMultiple drug resistanceColchicineIn vivoP-glycoproteinCell cycle checkpointPharmacologyCancer cellMicrotubuleIn vitroBiochemistryCell cycleCancerApoptosisBiologyCell biologyBiotechnologyAntibioticsGeneticsSynthesis and biological activityCancer therapeutics and mechanismsFerrocene Chemistry and Applications