Underlying beneficial effects of Rhubarb on constipation-induced inflammation, disorder of gut microbiome and metabolism
Han Gao, Chengwei He, Rongxuan Hua, Liang Chen, Boya Wang, Yixuan Du, Shuzi Xin, Yuexin Guo, Lei Gao, Lucia Zhang, Hongwei Shang, Jingdong Xu
Abstract
Graphical Abstract 1. Constipation leads to the enhanced thickness of muscle layer and sedimentation of collagenous fiber. 2. Constipation promotes not only the pro-inflammtory cytokines secretion but also damage the integrity of intestinal barrier. 3. The present results are significant in at least two major respects in the alternations of the diversity of gut microbiome along with the fluctuation of the fatty acid and bioamine in constipation mice. 4. One unanticipated finding is that the rhubarb extract has the potential to reverse the alterations induced by constipation.
Topics & Concepts
ConstipationMedicineGut floraGastroenterologyInternal medicinePhysiologyPharmacologyImmunologyGastrointestinal motility and disordersDigestive system and related healthDiet and metabolism studies