<i>In vivo</i> active organometallic-containing antimycotic agents
Riccardo Rubbiani, Tobias Weil, Noemi Tocci, Luciano Mastrobuoni, Severin Jeger, Marco Moretto, James Ng, Yan Lin, Jeannine Hess, Stefano Ferrari, Andres Kaech, Luke Young, John Spencer, Anthony L. Moore, Kevin Cariou, Giorgia Renga, Marilena Pariano, Luigina Romani, Gilles Gasser
Abstract
Fungal infections represent a global problem and there is an urgent need for new drugs. In this work, we prepared four novel organometallic derivatives of the frontline antifungal drug fluconazole with very promising <italic>in vivo</italic> activity.
Topics & Concepts
FluconazoleIn vivoAntifungalDrugChemistryPharmacologyMedicineMicrobiologyBiologyBiotechnologySynthesis and Biological EvaluationFerrocene Chemistry and ApplicationsAntifungal resistance and susceptibility