Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters
Valentin Sencio, Arnaud Machelart, Cyril Robil, Nicolas Benech, Eik Hoffmann, Chloé Galbert, Lucie Deryuter, Séverine Heumel, Aline Hantute-Ghesquier, Anne Flourens, Priscille Brodin, Fabrice Infanti, Virgile Richard, Jean Dubuisson, Corinne Grangette, Thierry Sulpice, Isabelle Wolowczuk, F Pinet, Vincent Prévot, Sandrine Belouzard, François Briand, Martine Duterque‐Coquillaud, Harry Sokol, François Trottein
Abstract
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; COVID-19, coronavirus disease 2019; SCFAs, short-chain fatty acids; dpi, day post-infection; RT-PCR, reverse transcription polymerase chain reaction; IL, interleukin. ACE2, angiotensin converting enzyme 2; TMPRSS2, transmembrane serine protease 2.
Topics & Concepts
Gut floraBiologyLachnospiraceaeImmunologyDiseaseMicrobiomeInflammationCoronavirusInflammatory bowel diseaseRespiratory systemLungMicrobiologyInternal medicineBacteriaCoronavirus disease 2019 (COVID-19)MedicineInfectious disease (medical specialty)BioinformaticsGeneticsAnatomy16S ribosomal RNAFirmicutesGut microbiota and healthClostridium difficile and Clostridium perfringens researchCOVID-19 Clinical Research Studies