LncRNA LINC01569 promotes M2 macrophage polarization to accelerate hypopharyngeal carcinoma progression through the miR-193a-5p/FADS1 signaling axis
Qilin Gong, Huaying Li, Jintian Song, Chang Lin
Abstract
LINC01569 is highly expressed in the TAMs of hypopharyngeal carcinoma. LINC01569 downregulation restrains macrophages from polarizing toward M2 through the miR-193a-5p/FADS1 signaling axis, thereby helping tumor cells escape inherent immune surveillance and promoting the occurrence and development of hypopharyngeal carcinoma.
Topics & Concepts
Downregulation and upregulationMacrophage polarizationGene knockdownCancer researchM2 MacrophageTransfectionChemistryCell growthFlow cytometryTumor microenvironmentMacrophageCell cultureBiologyMolecular biologyApoptosisIn vitroBiochemistryTumor cellsGeneGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCancer-related gene regulation