Circ-PGC increases the expression of FOXR2 by targeting miR-532-3p to promote the development of non-small cell lung cancer
Daokui Xia, Zhen Chen, Quan Liu
Abstract
. In conclusion, circ-PGC positively regulated FOXR2 expression by competitively binding to miR-532-3p, thereby promoting the development of NSCLC, and the Wnt/β-catenin signaling pathway might be activated by the circ-PGC/miR-532-3p/FOXR2 network.
Topics & Concepts
Gene knockdownViability assayDownregulation and upregulationBiologyCell growthMolecular biologyFlow cytometryCellWestern blotApoptosisCancer researchBiochemistryGeneCircular RNAs in diseasesFOXO transcription factor regulationCancer Mechanisms and Therapy