Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy
Zhaohuai Li, Mei Wang, Jia Ping Tan, Lei Zhu, Peng Zeng, Xiaozhen Chen, Lihui Xie, Runping Duan, Binyao Chen, Tianyu Tao, Rong Wang, Xianggui Wang, Wenru Su
Abstract
cytotoxic T lymphocytes with the terminal differentiation phenotype to be another source of interferon-γ, a molecule actively engaging in TAO pathogenesis. Cell-cell communication analysis reveals increased activity of CXCL8/ACKR1 and TNFSF4/TNFRSF4 interactions in TAO. This study provides a comprehensive local cell landscape of TAO and may be valuable for future therapy investigation.
Topics & Concepts
PathogenesisCellAdipose tissueBiologyCell biologyThyroidCytotoxic T cellInflammationRNAAdipogenesisCD8ImmunologyGeneGeneticsImmune systemIn vitroEndocrinologyOphthalmology and Eye DisordersProtein Tyrosine PhosphatasesThyroid Cancer Diagnosis and Treatment