Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffolds suppress osteosarcoma via TF/NOX2-associated ferroptosis while repairing bone defects
Zehao Jing, Wanqiong Yuan, Jiedong Wang, Renhua Ni, Yu Qin, Zhinan Mao, Feng Wei, Chunli Song, Yufeng Zheng, Hong Cai, Zhongjun Liu
Abstract
• Simvastatin/hydrogel-loaded 3D-printed titanium alloy scaffold (Sim-3DTi) was successfully constructed. • Sim-3DTi is biosafe while inhibiting osteosarcoma and promoting osteogenesis. • Sim-3DTi suppresses osteosarcoma via TF/NOX2-associated ferroptosis. • Sim-3DTi is a promising bone substitute for osteosarcoma-related bone defects.
Topics & Concepts
SimvastatinMaterials scienceAlloyTitaniumBiomedical engineeringMetallurgyMedicinePharmacologyRNA modifications and cancerFerroptosis and cancer prognosisMicroRNA in disease regulation