Michael addition-driven synthesis of cytotoxic palladium(<scp>ii</scp>) complexes from chromone thiosemicarbazones: investigation of anticancer activity through<i>in vitro</i>and<i>in vivo</i>studies
Jebiti Haribabu, Nithya Balakrishnan, Srividya Swaminathan, Dorothy Priyanka Dorairaj, Mohammad Azam, Mohamed Kasim Mohamed Subarkhan, Yu‐Lun Chang, Sodio C. N. Hsu, Pavel Štarha, Ramasamy Karvembu
Abstract
Michael addition derived Pd( ii ) complexes exhibited potential anticancer activity in HeLa cells via apoptosis. In vivo models showed that the complexes did not cause any harm to the treated mice, portraying better selectivity than cisplatin.
Topics & Concepts
ChemistryChromoneHeLaIn vivoIn vitroCytotoxic T cellCisplatinApoptosisSemicarbazoneStereochemistryPharmacologyBiochemistryChemotherapyInternal medicineMedicineBiologyBiotechnologyMetal complexes synthesis and propertiesSynthesis and biological activitySynthesis of Organic Compounds