Discovery of novel β-carboline-1,2,3-triazole hybrids as AChE/GSK-3β dual inhibitors for Alzheimer's disease treatment
Wenjie Liu, Liting Tian, Limeng Wu, Huanhua Chen, Nan Wang, Xin Liu, Changhao Zhao, Zhongchan Wu, Xiaowen Jiang, Qiong Wu, Zihua Xu, Wenwu Liu, Qingchun Zhao
Topics & Concepts
ChemistryAcetylcholinesteraseGSK-3IC50Glycogen synthaseADMEAchéPharmacologyCytotoxicityKinaseBiochemistryIn vitroEnzymeBiologyCholinesterase and Neurodegenerative DiseasesSynthesis and bioactivity of alkaloidsComputational Drug Discovery Methods