Structural modification based on the diclofenac scaffold: Achieving reduced colitis side effects through COX-2/NLRP3 selective inhibition
Zhiran Ju, Junde Xu, Keshuang Tang, Fen‐Er Chen
Topics & Concepts
ChemistryDiclofenacIC50PharmacologyColitisIn vivoEnzymeInflammatory bowel diseaseInflammationBiochemistryIn vitroImmunologyMedicineInternal medicineBiologyBiotechnologyDiseaseInflammasome and immune disordersInflammatory mediators and NSAID effectsNF-κB Signaling Pathways