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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

Rongxuan Zhu, Xianglai Ye, Xiaotong Lu, Liwei Xiao, Ming Yuan, Hong Zhao, Dong Guo, Ying Meng, Hongkuan Han, Shudi Luo, Qingang Wu, Xiaoming Jiang, Jun Xu, Zhonghui Tang, Yizhi Jane Tao, Zhimin Lu

2024Cell Metabolism226 citationsDOI

Topics & Concepts

Immune systemEvasion (ethics)HistoneFunction (biology)BiologyCell biologyGeneticsGeneEpigenetics and DNA MethylationRNA modifications and cancerCancer, Hypoxia, and Metabolism
ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion | Litcius