SIX4 promotes metastasis through STAT3 activation in breast cancer.
Xuling Sun, Jin Ma, Qianzhi Chen, Zhenlin Hou, Xuelai Luo, Guihua Wang, Jing Wang, Junbo Hu, Zhixin Cao
Abstract
. Mechanistically, SIX4 directly interacted with STAT3 and promoted the phosphorylated STAT3 nuclear translocation, thereby inducing EMT program activation. Collectively, our findings demonstrated that SIX4 may be a promising target for intervention to prevent cancer metastasis.
Topics & Concepts
MetastasisBreast cancerCancer researchGene knockdownCancerIn vivoBiologyMedicineInternal medicineCell cultureGeneticsCytokine Signaling Pathways and InteractionsMicroRNA in disease regulationinterferon and immune responses