Waning Immunity and the Second Wave: Some Projections for SARS-CoV-2
Chryssi Giannitsarou, Stephen M. Kissler, Flavio Toxvaerd
Abstract
This paper offers projections of future transmission dynamics for SARS-CoV-2 in an SEIRS model with demographics and waning immunity. In a stylized optimal control setting calibrated to the United States, we show that the disease is endemic in steady state and that its dynamics are characterized by damped oscillations. The magnitude of the oscillations depends on how fast immunity wanes. The optimal social distancing policy both curbs peak prevalence and postpones the infection waves relative to the uncontrolled dynamics. Last, we perform sensitivity analysis with respect to the duration of immunity, the infection fatality rate, and the planning horizon. (JEL I12, I18, J11)
Topics & Concepts
Stylized factTransmission (telecommunications)ImmunityHerd immunityDemographicsEpidemic modelDynamics (music)Duration (music)EconomicsBiologyDemographyVirologyPhysicsImmune systemMedicineImmunologyVaccinationEnvironmental healthPopulationComputer scienceKeynesian economicsAcousticsTelecommunicationsSociologyCOVID-19 epidemiological studiesMathematical and Theoretical Epidemiology and Ecology ModelsSARS-CoV-2 and COVID-19 Research