Rational discovery of molecular glue degraders via scalable chemical profiling
Cristina Mayor‐Ruiz, Sophie Bauer, Matthias Brand, Zuzanna Kozicka, Marton I. Siklos, Hana Imrichová, Ines H. Kaltheuner, Elisa Hahn, Kristina Seiler, Anna Koren, Georg Petzold, Michaela Fellner, Christoph Bock, André C. Müller, Johannes Zuber, Matthias Geyer, Nicolas H. Thomä, Stefan Kubicek, Georg E. Winter
Topics & Concepts
Ubiquitin ligaseDrug discoveryComputational biologyUbiquitinProfiling (computer programming)Ubiquitin-Protein LigasesBiologyChemistryComputer scienceBioinformaticsBiochemistryGeneOperating systemProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysHistone Deacetylase Inhibitors Research