Advances in antitumor nanomedicine based on functional metal–organic frameworks beyond drug carriers
Qin Wei, Yihan Wu, Fangfang Liu, Jiao Cao, Jinliang Liu
Abstract
modification of organic linkers), they can respond to tumor microenvironments to realize on-demand treatment. By incorporating porphyrin-based ligands (photosensitizers for photodynamic therapy) or high-Z metal ions (radiosensitizers for radiotherapy) into the scaffold of MOFs, MOFs themselves can act as anticancer therapeutic agents. In this review, we highlight the application of MOFs from the above-mentioned aspects and discuss the prospects and challenges for using MOFs in stimuli-responsive imaging-guided antitumor therapy.
Topics & Concepts
Metal-organic frameworkNanocarriersNanotechnologyMaterials scienceNanomedicineDrug deliveryNanomaterialsBiocompatibilityMetal ions in aqueous solutionRational designPhotodynamic therapyDrugMetalNanoparticleChemistryOrganic chemistryMedicinePharmacologyMetallurgyAdsorptionMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery