Forwards and backwards – synthesis of <i>Laurencia</i> natural products using a biomimetic and retrobiomimetic strategy incorporating structural reassignment of laurefurenynes C–F
Hau Sun Sam Chan, Amber L. Thompson, Kirsten E. Christensen, Jonathan W. Burton
Abstract
The synthesis and structural reassignment of laurefurenynes C–F has been achieved, with the new structures fitting with a proposed biosynthesis. Also reported is the synthesis of <italic>ent</italic>-laurencin and <italic>ent</italic>-deacetyllaurencin via a retrobiomimetic approach.
Topics & Concepts
StereochemistryChemistryChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacologyMarine Sponges and Natural Products