Immune and Genome Engineering as the Future of Transplantable Tissue
Jennifer Elisseeff, Stephen F. Badylak, Jef D. Boeke
Abstract
Dramatic advancements in the use of synthetic and mechanical devices to replace tissues have been made, but restoring tissue and organ structure and function remains challenging. This review discusses the origins, innovations, and future of regenerative medicine and transplantation, which are closely intertwined.
Topics & Concepts
Immune systemBiologyRegenerative medicineFunction (biology)Tissue engineeringComputational biologyGenome engineeringGenomeBiomedicineGenome editingTissue Engineering and Regenerative MedicineXenotransplantation and immune responseBiomedical Ethics and Regulation