A bifunctional molecule-assisted synthesis of mimics for use in probing the ubiquitination system
Qingyun Zheng, Tian Wang, Junxiong Mao, Guo‐Chao Chu, Lujun Liang, Yangwode Jing, Chong Zuo, Yuanyuan Yu, Honggang Hu, Man Pan
Topics & Concepts
Deubiquitinating enzymeUbiquitinBifunctionalCysteineNative chemical ligationThioesterCovalent bondChemistryBiochemistrySmall moleculeBiophysicsEnzymeCombinatorial chemistryStereochemistryBiologyOrganic chemistryCatalysisGeneUbiquitin and proteasome pathwaysAutophagy in Disease and TherapyProtein Degradation and Inhibitors