Efficient Maternofetal Transplacental Transfer of Anti- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Antibodies After Antenatal SARS-CoV-2 BNT162b2 Messenger RNA Vaccination
Amihai Rottenstreich, Gila Zarbiv, Esther Oiknine‐Djian, Roy Zigron, Dana G. Wolf, Shay Porat
Abstract
Maternal and cord blood sera were collected from 20 parturients who received the BNT162b2 vaccine. All women and infants were positive for anti S- and anti-receptor binding domain antibody-specific immunoglobulin G. Cord blood antibody concentrations were correlated to maternal levels and to time since vaccination. Antenatal severe acute respiratory syndrome coronavirus 2 vaccination may provide maternal and neonatal protection.
Topics & Concepts
MedicineTransplacentalVaccinationAntibodyCoronavirusCord bloodVirologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)ImmunologySevere acute respiratory syndrome coronavirusCoronavirus disease 2019 (COVID-19)FetusPregnancyInternal medicinePlacentaBiologyGeneticsInfectious disease (medical specialty)DiseaseCOVID-19 Impact on ReproductionReproductive System and PregnancyVaccine Coverage and Hesitancy