Sex Disparities in the Clinical Characteristics, Synchronous Distant Metastasis Occurrence and Prognosis: A Pan-cancer Analysis
Yutong Wang, Ziqian Zeng, Mingshuang Tang, Min Zhang, Ye Bai, Huijie Cui, Yao Xu, Xu Guo, Wenjuan Ma, Guijun Xu, Lisha Qi, Jingyi Wang, Siyu Chen, Dongqing Gu, Min Mao, Xin Wang, Chao Zhang
Abstract
Background: This study aims to assess the sex disparities in clinical characteristics and synchronous distant metastasis occurrence at diagnosis, as well as the subsequent prognosis in non-sex-specific cancers. Methods: The study included details from patients diagnosed with non-sex-specific cancers, during the period from 2010 to 2016, in the Surveillance, Epidemiology, and End Results (SEER) program. The distant metastasis prevalence and subsequent survival time were summarized in the total population and the population with specific cancers of different systems. The multivariable logistic and the Cox proportional hazards regressions were applied to evaluate the sex effect on distant metastasis occurrence and prognosis. The results were combined using meta-analysis.