Discovery of novel triple targeting G‑quadruplex and topoisomerase 1/2 ligands from natural products evodiamine and rutaecarpine
Haibo Wang, Xuexin Bai, Ya‐Hui Huang, Yueru Chen, Guoqiang Dong, Tian‐Miao Ou, Shanchao Wu, Defeng Xu, Chunquan Sheng
Topics & Concepts
RutaecarpineEvodiamineChemistryNatural productLead compoundDrug discoveryCombinatorial chemistryScaffoldStereochemistryBiochemistryComputer scienceChromatographyIn vitroDatabaseCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsDNA and Nucleic Acid Chemistry