Impairment of PGC-1α-mediated mitochondrial biogenesis precedes mitochondrial dysfunction and Alzheimer's pathology in the 3xTg mouse model of Alzheimer's disease
Monique Patrício Singulani, Carolina Parga Martins Pereira, Ana Flávia Fernandes Ferreira, Priscila Crespo Garcia, Gustavo Duarte Ferrari, Luciane C. Alberici, Luiz Roberto Britto
Topics & Concepts
TFAMMitochondrial biogenesisNRF1DNAJA3MitochondrionBiogenesisCREBBiologyOrganelle biogenesisMitochondrial DNACell biologyEndocrinologyInternal medicineTranscription factorMedicinemitochondrial fusionGeneticsGeneAlzheimer's disease research and treatmentsMitochondrial Function and PathologyCholinesterase and Neurodegenerative Diseases