Modeling lung adenocarcinoma metastases using patient-derived organoids
Yuan Liu, Manendra B. Lankadasari, Joel Rosiene, Kofi E. Johnson, Juan Zhou, Samhita Bapat, Lai-Fong L Chow-Tsang, Huasong Tian, Brooke Mastrogiacomo, Di He, James G. Connolly, Harry B. Lengel, Raul Caso, Elizabeth G. Dunne, Cameron N. Fick, Gaetano Rocco, Smita Sihag, James M. Isbell, Mathew J. Bott, Bob T. Li, Piro Lito, Cameron Brennan, Mark H. Bilsky, Natasha Rekhtman, Prasad S. Adusumilli, Marty W. Mayo, Marcin Imieliński, David R. Jones
Abstract
PDOs to sotorasib demonstrates that the model can examine the efficacy of treatments to suppress metastasis and identify mechanisms of drug resistance. Finally, our PDO model cocultured with autologous peripheral blood mononuclear cells can potentially be used to determine the optimal immune-priming strategy for individual patients with LUAD.