Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit
Javier Díaz-Alonso, Wade Morishita, Salvatore Incontro, Jeffrey A. Simms, Julia Holtzman, Michael Gill, Lennart Mucke, Robert C. Malenka, Roger A. Nicoll
Abstract
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.
Topics & Concepts
AMPA receptorLong-term potentiationProtein subunitNeuroscienceCTDChemistryTerm (time)Cell biologyReceptorBiologyBiophysicsNMDA receptorBiochemistryPhysicsOceanographyGeologyQuantum mechanicsGeneNeuroscience and Neuropharmacology ResearchPhotoreceptor and optogenetics researchNeural dynamics and brain function