Heart Failure and Diabetes Mellitus: Dangerous Liaisons
Hae‐Young Lee
Abstract
Patients with diabetes mellitus (DM) have a higher prevalence of heart failure (HF) than those without it. Approximately 40% of HF patients have DM, having poorer outcomes than those without DM. Myocardial ischemia caused by endothelial dysfunction, renal dysfunction, obesity, and impaired myocardial energetics is pathophysiology of DM-induced HF (DM-HF). Also, patients with HF show an increased risk for the onset of DM due to several mechanisms including insulin resistance. This review is focused on the epidemiology, pathogenic mechanism and treatment strategy of DM-HF.
Topics & Concepts
Diabetes mellitusMedicineHeart failureInternal medicineCardiologyPathophysiologyInsulin resistanceObesityEndothelial dysfunctionEpidemiologyMyocardial ischemiaIschemiaEndocrinologyCardiovascular Function and Risk FactorsHeart Failure Treatment and ManagementDiabetes Treatment and Management