Inflammatory Arthritis Induced by Anti-Programmed Death-1 Shown in 68Ga-FAPI PET/CT in a Patient With Esophageal Carcinoma
Yaping Luo, Qingqing Pan, Huaxia Yang, Fang Li, Fengchun Zhang
Abstract
ABSTRACT: A 30-year-old woman with esophageal squamous cell carcinoma experienced joint pain and swelling in bilateral knees, wrists, and hand joints during the course of neoadjuvant immunochemotherapy. She underwent 18F-FDG and 68Ga-FAPI PET/CT for response assessment of the tumor and evaluating her arthritis. 68Ga-FAPI PET/CT detected intense uptake in multiple joints, consistent with her polyarthritis. However, these joints showed only mild FDG uptake. The tumor was in complete response, and her polyarthritis was considered as inflammatory arthritis induced by anti-PD1.
Topics & Concepts
MedicinePolyarthritisArthritisCarcinomaEsophageal squamous cell carcinomaColonic CarcinomaNuclear medicineRadiologyPathologyInternal medicinePeptidase Inhibition and AnalysisCardiac Structural Anomalies and RepairNeuropeptides and Animal Physiology