Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model
Nadeem Moghal, Quan Li, Erin Stewart, Roya Navab, Masashi Mikubo, Elisa D’Arcangelo, Sebastião N. Martins-Filho, Vibha Raghavan, Nhu‐An Pham, Ming Li, Frances A. Shepherd, Geoffrey Liu, Ming‐Sound Tsao
Topics & Concepts
Cancer researchErlotinibMedicineTranscriptomePopulationStromal cellLung cancerTyrosine-kinase inhibitorTyrosine kinaseCancerEpidermal growth factor receptorBiologyInternal medicineReceptorGene expressionGeneGeneticsEnvironmental healthSingle-cell and spatial transcriptomicsLung Cancer Treatments and MutationsCancer Immunotherapy and Biomarkers