Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking
Aftab Alam, Mumtaz Ali, Zainab Zainab, Abdul Latif, Najeeb Ur Rehman, Abdul Jabbar Shah, Irfan Amir Khan, Muhammad Ayaz, Sajjad Ur Rahman, Ahmed Al‐Harrasi, Manzoor Ahmad
Topics & Concepts
ChemistryFlurbiprofenAnalgesicPharmacophoreIn vivoPharmacologyDocking (animal)Acute toxicityHot plate testStereochemistryToxicityBiochemistryReceptorMedicineOrganic chemistryBiotechnologyNociceptionNursingBiologySynthesis and biological activityPhenothiazines and Benzothiazines Synthesis and ActivitiesSynthesis and Characterization of Heterocyclic Compounds