Pd((<i>R</i>)-DTBM-SEGphos)Cl<sub>2</sub>-catalyzed kinetic resolution of tertiary propargylic alcohols
Jie Wang, Wei‐Feng Zheng, Yuling Li, Yinlong Guo, Hui Qian, Shengming Ma
Abstract
A variety of optically active tertiary propargylic alcohols and tetrasubstituted 2,3-allenoic acids have been synthesized via a Pd(( R )-DTBM-SEGphos)Cl 2 -catalyzed carboxylative kinetic resolution reaction of racemic tertiary propargylic alcohols.
Topics & Concepts
ChemistryKinetic resolutionTertiary alcoholsCatalysisKinetic energyOrganic chemistryMedicinal chemistryOptically activeEnantioselective synthesisPhysicsQuantum mechanicsCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsSynthetic Organic Chemistry Methods