PRRSV nonstructural protein 11 degrades swine ISG15 by its endoribonuclease activity to antagonize antiviral immune response
Dandan Jiang, Maojuan He, Chao Sui, Xiangju Wu, Yue Hu, Xiaoyan Cong, Juntong Li, Yijun Du, Jing Qi
Topics & Concepts
ISG15BiologyPorcine reproductive and respiratory syndrome virusEndoribonucleaseVirologyInterferonInnate immune systemArterivirusViral replicationVirusImmune systemAutophagyNidoviralesInterferon-stimulated geneCoronavirusCell biologyRNAGeneUbiquitinGeneticsApoptosisInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)DiseaseRNase PPathologyMedicineAnimal Virus Infections StudiesVirus-based gene therapy researchinterferon and immune responses