Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease
Huan-Yun Chen, Chin‐Hsien Lin, Shu‐Chun Teng
Abstract
mutant mice and in PD patients. Together, our data reveal stress-induced p53-BAG5-HSP70 regulation that provides a potential therapeutic angle for PD.
Topics & Concepts
Parkinson's diseaseDiseaseNeuroscienceAlpha-synucleinCell biologyBiologyChemistryInternal medicineMedicinePARP inhibition in cancer therapyParkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatments